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Current Opinion in Microbiology

From known knowns to unknown unknowns: synthetic biology paths to antimicrobial discovery

Siqiang Chen, Hao Xiang, Ying Chen, Helge B. Bode, Yi-Ming Shi

Curr. Opin. Microbiol. 2026, 91, 102759.

Chemical Science

Lipid-donor-anchored genome mining uncovers dioxanopeptins, antibacterial lipopeptides with a 1,3-dioxane functionalized polyunsaturated lipid tail

Ying Chen^†, Yunsheng Chen^†, Hao Xiang^†, Changqi Luo, Jiaqi Duan, Kun Hu, Xiaohong Zheng, Jing Liu, Yongbo Xue, Yi-Ming Shi

Chem. Sci. 2026, 17, 8229–8241.

ChemMedChem

Bacterial Secondary Metabolites Embedded in Producer Cell Membranes and Antibiotics Targeting Their Biosynthesis

Zhao Xia^†, Hao Xiang^†, Yi-Ming Shi

ChemMedChem 2024, 19, e202400469.

Natural Product Reports

Exploring nature's battlefield: organismic interactions in the discovery of bioactive natural products

Yuyang Wang, Yan-Ni Shi, Hao Xiang, Yi-Ming Shi

Nat. Prod. Rep. 2024, 41, 1630–1651.

ACS Catalysis

Structural and Computational Insights into the Noncanonical Aromatization in Fungal Polyketide Biosynthesis

Hang Wang, Chao Peng, Xiao-Xuan Chen, Hao-Yang Wang, Run Yang, Hao Xiang, Qiu-Fen Hu, Ling Liu, Lung Wa Chung, Yudai Matsuda, Wei-Guang Wang

ACS Catal. 2024, 14, 10796–10805.

Angewandte Chemie International Edition

Mechanism Behind the Programmed Biosynthesis of Heterotrimeric Fungal Depside Thielavin A

Qiaolin Ji, Hao Xiang, Wei-Guang Wang, Yudai Matsuda

Angew. Chem. Int. Ed. 2024, 63, e202402663.

Journal of the American Chemical Society

Ketoreductase Domain-Catalyzed Polyketide Chain Release in Fungal Alkyl Salicylaldehyde Biosynthesis

Run Yang^†, Jian Feng^†, Hao Xiang^†, Bin Cheng^†, Li-Dong Shao, Yan-Ping Li, Hang Wang, Qiu-Fen Hu, Wei-Lie Xiao, Yudai Matsuda, Wei-Guang Wang

J. Am. Chem. Soc. 2023, 145, 11293–11300.