Current
PhD student
University of Chinese Academy of Sciences
Research at SyM Lab, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences.
Curriculum vitae
Hao Xiang 向浩
Computational biology · Genome mining · Natural products
PhD student at the University of Chinese Academy of Sciences, working at SyM Lab, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences.
Education
2021 – 2024
MSc in Chemical Biology
Yunnan Minzu University
Genome mining of functional small molecules from endophytic fungi associated with ethnic medicinal plants.
2016 – 2020
BSc in Bioinformatics
Chongqing University of Posts and Telecommunications
Research
experience
2023 – 2024
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
Visiting student
Computational methods for mining microbial small molecules.
Aug 2023 – Jan 2024
City University of Hong Kong
Research experience
Molecular docking and dynamics for thielavin A biosynthesis; published in Angewandte Chemie International Edition in 2024.
2022 – 2023
Yunnan Minzu University
Natural-product genome mining
Mining biosynthetic gene clusters from endophytic fungi and analyzing candidate resistance genes. Related work on polyketide biosynthesis was published in JACS (2023) and ACS Catalysis (2024).
2022 – 2023
Yunnan Minzu University
Additional research
Aroma-component analysis for reconstituted tobacco leaves; local AlphaFold2 deployment and protein-domain analysis for molecular docking.
Research methods
Genome mining & sequence analysis
Biosynthetic gene-cluster detection, comparative genomics, protein annotation, antiSMASH and cblaster workflows.
Structural & computational biology
Molecular docking, molecular dynamics, protein-structure prediction and biosynthetic enzyme analysis.
Machine learning
Sequence-based learning and exploration of protein language models for biological function prediction.
Publications
- Siqiang Chen, Hao Xiang, Ying Chen, Helge B. Bode, Yi-Ming Shi . From known knowns to unknown unknowns: synthetic biology paths to antimicrobial discovery.Curr. Opin. Microbiol. 2026, 91, 102759.
- Ying Chen†, Yunsheng Chen†, Hao Xiang†, Changqi Luo, Jiaqi Duan, Kun Hu, Xiaohong Zheng, Jing Liu, Yongbo Xue, Yi-Ming Shi . Lipid-donor-anchored genome mining uncovers dioxanopeptins, antibacterial lipopeptides with a 1,3-dioxane functionalized polyunsaturated lipid tail.Chem. Sci. 2026, 17, 8229–8241.
- Zhao Xia†, Hao Xiang†, Yi-Ming Shi . Bacterial Secondary Metabolites Embedded in Producer Cell Membranes and Antibiotics Targeting Their Biosynthesis.ChemMedChem 2024, 19, e202400469.
- Yuyang Wang, Yan-Ni Shi, Hao Xiang, Yi-Ming Shi . Exploring nature's battlefield: organismic interactions in the discovery of bioactive natural products.Nat. Prod. Rep. 2024, 41, 1630–1651.
- Hang Wang, Chao Peng, Xiao-Xuan Chen, Hao-Yang Wang, Run Yang, Hao Xiang, Qiu-Fen Hu, Ling Liu, Lung Wa Chung, Yudai Matsuda, Wei-Guang Wang . Structural and Computational Insights into the Noncanonical Aromatization in Fungal Polyketide Biosynthesis.ACS Catal. 2024, 14, 10796–10805.
- Qiaolin Ji, Hao Xiang, Wei-Guang Wang, Yudai Matsuda . Mechanism Behind the Programmed Biosynthesis of Heterotrimeric Fungal Depside Thielavin A.Angew. Chem. Int. Ed. 2024, 63, e202402663.
- Run Yang†, Jian Feng†, Hao Xiang†, Bin Cheng†, Li-Dong Shao, Yan-Ping Li, Hang Wang, Qiu-Fen Hu, Wei-Lie Xiao, Yudai Matsuda, Wei-Guang Wang . Ketoreductase Domain-Catalyzed Polyketide Chain Release in Fungal Alkyl Salicylaldehyde Biosynthesis.J. Am. Chem. Soc. 2023, 145, 11293–11300.
† Equal contribution. Publication links & files →
Awards
- National Scholarship for Graduate Excellence
- First-Class Academic Scholarship
- Third-Class Academic Scholarship
- Second-Class Undergraduate Academic Scholarship