Research output 2023–2026

Publications

Genome mining, biosynthetic mechanisms and natural-product discovery.

ORCID profile

7 publications

† Equal contribution

2026Review

Current Opinion in Microbiology

From known knowns to unknown unknowns: synthetic biology paths to antimicrobial discovery

Siqiang Chen, Hao Xiang, Ying Chen, Helge B. Bode, Yi-Ming Shi

Curr. Opin. Microbiol. 2026, 91, 102759.

DOI

2026Research articleCo-first author

Chemical Science

Lipid-donor-anchored genome mining uncovers dioxanopeptins, antibacterial lipopeptides with a 1,3-dioxane functionalized polyunsaturated lipid tail

Ying Chen^†, Yunsheng Chen^†, Hao Xiang^†, Changqi Luo, Jiaqi Duan, Kun Hu, Xiaohong Zheng, Jing Liu, Yongbo Xue, Yi-Ming Shi

Chem. Sci. 2026, 17, 8229–8241.

DOI Full text Code

2024ReviewCo-first author

ChemMedChem

Bacterial Secondary Metabolites Embedded in Producer Cell Membranes and Antibiotics Targeting Their Biosynthesis

Zhao Xia^†, Hao Xiang^†, Yi-Ming Shi

ChemMedChem 2024, 19, e202400469.

DOI

2024Review

Natural Product Reports

Exploring nature's battlefield: organismic interactions in the discovery of bioactive natural products

Yuyang Wang, Yan-Ni Shi, Hao Xiang, Yi-Ming Shi

Nat. Prod. Rep. 2024, 41, 1630–1651.

DOI PDF

2024Research article

ACS Catalysis

Structural and Computational Insights into the Noncanonical Aromatization in Fungal Polyketide Biosynthesis

Hang Wang, Chao Peng, Xiao-Xuan Chen, Hao-Yang Wang, Run Yang, Hao Xiang, Qiu-Fen Hu, Ling Liu, Lung Wa Chung, Yudai Matsuda, Wei-Guang Wang

ACS Catal. 2024, 14, 10796–10805.

DOI PDF

2024Research article

Angewandte Chemie International Edition

Mechanism Behind the Programmed Biosynthesis of Heterotrimeric Fungal Depside Thielavin A

Qiaolin Ji, Hao Xiang, Wei-Guang Wang, Yudai Matsuda

Angew. Chem. Int. Ed. 2024, 63, e202402663.

DOI PDF

2023Research articleCo-first author

Journal of the American Chemical Society

Ketoreductase Domain-Catalyzed Polyketide Chain Release in Fungal Alkyl Salicylaldehyde Biosynthesis

Run Yang^†, Jian Feng^†, Hao Xiang^†, Bin Cheng^†, Li-Dong Shao, Yan-Ping Li, Hang Wang, Qiu-Fen Hu, Wei-Lie Xiao, Yudai Matsuda, Wei-Guang Wang

J. Am. Chem. Soc. 2023, 145, 11293–11300.

DOI PDF

From known knowns to unknown unknowns: synthetic biology paths to antimicrobial discovery

Lipid-donor-anchored genome mining uncovers dioxanopeptins, antibacterial lipopeptides with a 1,3-dioxane functionalized polyunsaturated lipid tail

Bacterial Secondary Metabolites Embedded in Producer Cell Membranes and Antibiotics Targeting Their Biosynthesis

Exploring nature's battlefield: organismic interactions in the discovery of bioactive natural products

Structural and Computational Insights into the Noncanonical Aromatization in Fungal Polyketide Biosynthesis

Mechanism Behind the Programmed Biosynthesis of Heterotrimeric Fungal Depside Thielavin A

Ketoreductase Domain-Catalyzed Polyketide Chain Release in Fungal Alkyl Salicylaldehyde Biosynthesis

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