#2 Mechanism Behind the Programmed Biosynthesis of Heterotrimeric Fungal Depside Thielavin A
Published in Angewandte Chemie International Edition, 2024
The polyketide synthase ThiA that forms the heterotrimeric fungal depside thielavin A (1) has been identified and characterized. The thioesterase (TE) domain of ThiA was found to perform two consecutive esterification reactions as well as subsequent hydrolysis, and a plausible reaction mechanism for the TE-catalyzed reactions has been proposed. Furthermore, this study provides insights into how ThiA selectivity yields the heterotrimeric product.
Recommended citation: Angew. Chem. Int. Ed. 2024, 63, e202402663.
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