Hao XIANG – Academic CV
Email: h.xiang@siat.ac.cn
Current Affiliation: Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences
🎓 Education
- Master of Science in Chemical Biology
Yunnan Minzu University, 09/2021 – 06/2024- GPA: 80/100
- Research focus: Big data mining of functional small molecules from endophytic fungi in ethnic medicine.
- Bachelor of Science in Bioinformatics
Chongqing University of Posts and Telecommunications, 09/2016 – 06/2020- GPA: 80/100
- Visiting Student (Joint Master’s Degree)
Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, 03/2023 – Present- Research Focus: Construction of data mining methods for microbial small molecules.
🔬 Research Experience
1. Unveiling the Mechanism of Heterotrimeric Fungal Depside Thielavin A Biosynthesis
City University of Hong Kong, 08/2023 – 01/2024
- Conducted molecular dynamics simulations and molecular docking tasks.
- Completed a manuscript submitted to Angewandte Chemie International Edition.
2. Big Data Mining for Functional Small Molecules from Endophytic Fungi in Ethnic Medicine
Yunnan Minzu University, 09/2022 – 06/2023
- Developed a method to identify potential resistance genes within biosynthetic gene clusters.
- Published findings as co-first author in Journal of the American Chemical Society (JACS).
- Conducted extended analysis on cupin-domain protein, submitted to Angewandte Chemie International Edition.
3. Development of Multi-Level Flavour Loading Technology for Reconstructed Tobacco Leaves
Yunnan Minzu University, 01/2022 – 06/2023
- Analyzed aroma components of Yunnan sun-cured tobacco.
- Provided technical support for the utilization of Yunnan’s tobacco resources.
4. Alphafold2 Functional Iteration Deployment
Yunnan Minzu University, 10/2022
- Deployed AlphaFold2 source code and completed local database setup.
- Identified the ACP structural domain of StrA protein for molecular docking analysis.
🏆 Awards and Honours
- National Scholarship for Graduate Excellence (National-level), 10/2023
- First-Class Academic Scholarship (University-level), 09/2022
- Third-Class Academic Scholarship (University-level), 09/2021
- Second-Class Academic Scholarship (Undergraduate, University-level), 09/2018
📚 Publications
- Ketoreductase Domain-Catalyzed Polyketide Chain Release in Fungal Alkyl Salicylaldehyde Biosynthesis
Journal of the American Chemical Society (JACS), 2023 - Mechanism Behind the Programmed Biosynthesis of Heterotrimeric Fungal Depside Thielavin A
Angewandte Chemie International Edition (Angew), 2024 - Structural and Computational Insights into the Noncanonical Aromatization in Fungal Polyketide Biosynthesis
ACS Catalysis (ACS Catalysis), 2024 - Exploring nature’s battlefield: organismic interactions in the discovery of bioactive natural products
Natural Product Reports (NPR), 2024
🛠 Skills
- Molecular Dynamics & Docking: Experienced in computational simulations.
- Genome Mining & Bioinformatics: Expertise in mining biosynthetic gene clusters.
- Machine Learning & AlphaFold2: Applied machine learning in structural biology.
- Scientific Writing: Published papers in top journals (JACS, Angewandte Chemie, ACS Catalysis, NPR).
📬 Contact
Feel free to reach out to me via email for collaborations or inquiries related to computational biology and natural product discovery.